I have a Lowepro Streamline 100 and carry everything in my signature plus 2 spare batteries and a Samsung Galaxy. This is worn across my shoulder for easy access from the front. I can't fit any filters in there (in their cases), so they go in my backpack. With a body and 4 lenses, it's a snug fit, but I barely notice the weight and it doesn't interfere with my hands for grabbing onto rocks and the like while scrambling up slopes. I've also dropped this down the equivalent of a flight of stairs with all my gear in with no damage to anything aside from needing a dust-ff. I've trekked for a couple of days with this kit (not 2200 miles though!)
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http://www.flickr.com/photos/53061745@N02/Panasonic G3: 9-18mm, 14mm, 20mm, 45mm