I'm a fairly new owner of the 70-200 and I'm still trying to figure out the best method of handling it. I was used to the 18-200mm where the zoom and focus rings are reversed but I'm being caught out with this pro lens on the best way to position my left hand. I'm hoping it will come with practice. :)
It is a truly epic piece of glass though.
I've only ever found one way of holding this lens. It's not as intuitive as the 80-200 2.8 1-Touch edition, but my hand controls focus override & zoom well enough.